Presentation

Personnel : 10 persons including 6 with post-doctorate

Key Words
Parasite - pathogeny - resistance to medication - virulence-proteases – therapeutic targets

Know-How

• Cellular culture
• Antigen/antibodies detection
• Molecular biology (conventional and real time)
• Large-volume water filtration for immunomagnetic parasite separation
• Protein purification
• Flow cytometry
• Bidimensional electrophoresis

Research subjects

• Antiparasite resistance mechanisms
• Membrane transport
• Virulence factor (metallo-proteinases)
• Extra cellular membrane transfer
• Pathogens
• Parasites in the environment.

Equipment

• Molecular biology
• Cellular culture
• Conventional and transgenic small animals
• Specific equipment for antigen-antibodies analysis

Patents

• In progress
  • T.gondii parasite ABC-carrier-type protein (efflux, resistance …)

Partnerships

• INDUSTRIAL
  • PALL LIFE Sciences
  • ARGENE BIOSOFT
  • ABBOTT Diagnostics…
• ACADEMIC
• 33 CHUs within Toxoplasmose CNR & Toxoplasma CRB projects
• Special partnerships: Limoges, Grenoble, Paris VI
• OTHERS
  • Institut de Veille Sanitaire

Specificities

• Toxoplasma Biological Resource Centre (supported by Research Ministry and Inserm)
• Toxoplasmose National Reference Centre (national coordinator: I. Villena)
• Toxoplasme Biological Resource Centre, unique in France