Environmental Stress and aquatic biomonitoring (SEBIO) - LE HAVRE / INERIS - UMR I-02


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Team presentation

Given the presence of contaminants related to human activities in natural environments, current researches in the laboratory are aimed i) a better understanding of fundamental mechanisms underlying their toxic effects on animal organisms, ii) the definition of precocious and predictive responses of the toxic hazard and their potential use in monitoring networks. The unit researches are organized around three axis: i) preproduction and endocrinology, ii) immunity and defense capacities and iii) energy and metabolism.


The 1st of January 2018, the composition of the unit was: 30 teacher-researchers and researchers; 16 engineers or technicians with permanent contracts, and 25 doctoral students, post-doctoral and engineers or technicians in fixed-term contracts.

Key words

Ecotoxicology, biomarkers, bioassays, energy metabolism, genotoxicity, reprotoxicity, endocrine disruptors, immunotoxicity, chemical stress, biological stress, vertebrates, invertebrates, biomonitoring, continuum

Research topics

Theme 1: Improve our knowledge on the mechanisms of toxicity of chemical and biological contaminants on aquatic organisms and identification of interest markers for biomonitoring.

Theme 2: Lift the locks of the use of these markers/tools (biomarkers, bioassays) in biomonitoring and environmental diagnosis.


  • Physico-chemical parameters of water analysis
  • Trace metals analysis
  • Molecular biology
  • DNA integrity
  • Enzymology
  • Histology and Cytology
  • Flow cytometry



Irstea, IFREMER, INRA, IRSN, CEA, University of Reims(EA3800 PROTAL, ICMR UMR 7312), University of Lorraine (LIEC, UMR CNRS 7360, LCPME UMR 7564), Université Catholique de l’Ouest (EA2160 MMS), University of Montpellier (UMR 5119 Ecosym UM2 - CNRS – IFREMER), University of Pau (ECOBIOP UMR 1224 INRA), University of Perpignan (IMAGES, EA 4218 ; CEFREM UMR 5110 CNRS, 2EI UMR CNRS 5244), Sorbonne University (METIS, UMR 7619 CNRS), University of Lille (UMR 8187 LOG) University Côte d’Opale, University of Bordeaux (UMR 5805 EPOC), University of Caen (UMR 7208 BOREA), University of Rouen (UMR 6143 M2C)


CIRE (Québec, Canada), INRS, (Armand-Frappier Institute, Montréal Quebec Canada), CISA-INIA (Madrid Espagne), University of Ternopil (Ukraine), University of Sussex, Marine Biological association, University of Liège ; University of Namur; CSIC of Barcelona ; Ternopil V. Hnatyuk National Pedagogical University, Ukraine ; Nicolaus Copernicus University, Torun, Poland ; Department of Ecology, Environment and Plant Sciences, Stockholm University, Sweden, University of Sfax (Tunisia).University of Tubingen (Germany), University College Cork (Irlande), University of Algarve (Portugal)



Plateform SEBIO:

  • Mesocosms (12) : INERIS
  • Cytometry : URCA/INERIS

Palteform SCALE (ULHN):

  • chemical and physical analysis in environmental matrix
  • microscopy and flow cytometry
  • microbiology and molecular ecology

Equipment’s (on the three sites of SEBIO) :

Equipment for maintenance and exposure of aquatic organisms (vertebrates and invertebrates) under la conditions

Molecular biology :
  • q-PCR
  • Nanodrop
  • Digital Droplet-PCR
  • Automated biochemistry platform for the implementation of biochemical assays in 96- and 384-well microplates
  • Robot Thermo Scientific Gallery™
  • HPLC
  • Two-dimensional electrophoresis
  • UPLC Q-TOF ; QTrap
Cellular biology:
  • Flow cytometry
  • Genotoxicity (comet assay)
Histology :
  • All equipments to prepare samples for optical and electronic microscopy.
  • Microscopes (optical and fluorescence)
  • Cryotome
Trace metals analysis in different matrix:
  • Absorption Atomic Spectrometry (furnace, flame)


Contact information

Mme Bart Florence (03 26 91 85 75)

Organizational chart



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