Organisation
Immune dysregulation and tissue remodelling in cancer, autoimmune and inflammatory diseases (IRMAIC) - UR 7509
Contact information
Pr. Potteaux Stephane, Director
stephane.potteaux@univ-reims.fr
Pôle Santé URCA, Bâtiment Recherche,
51 rue Cognacq-Jay
51095 Reims Cedex
Secretariate
Traore Marie
marie.traore@univ-reims.fr
Tel : 02 26 91 85 51
Team presentation
EA 7509 "Immuno-regulation in autoimmune and inflammatory diseases and cancer" (IRMAIC) is a research unit of the Reims Champagne-Ardenne’s University.
The unit's scientific project focuses on a better understanding of the cellular and molecular mechanisms involved in the development of immune-mediated inflammatory diseases. The aim is to propose new biomonitoring, diagnostic and treatment strategies.
The project applies to several pathologies:
- Autoimmune diseases with cutaneous manifestations: Bullous pemphigoid and systemic scleroderma
- Pulmonary diseases or diseases with a pulmonary component: chronic obstructive pulmonary disease (COPD) and respiratory infections with Respiratory Syncitial Virus and SARS-CoV-2; primitive humoral deficiency.
- Cancers: triple-negative breast cancer, chronic lymphocytic leukemia, COPD-associated lung cancers
Members
11 teacher-researchers, 1 full-time researcher, 2 hospital doctors, 6 BIATSS staff, 2 clinical research associates and 4 PhD students.
Key words
Immunoregulation, Elastin peptides, Emphysema, Cytokines, chemokines, immune checkpoints, RSV, SARS-CoV-2, Bullous Pemphigoid, Systemic sclerosis, CLL, COPD, Breast cancer.
Research topics
Influence of the inflammatory response in the immune and non-immune cell response of the host: role of the cytokines associated with the IL-17 pathway.
Know-how
- Translational research in connection with the Rare Diseases Reference Centre " Autoimmune Bullous Diseases" located in the Dermatology Department of the Reims University Hospital, the Pathology laboratory of the Jean Godinot Institute and the Department of Respiratory Diseases of the CHU R Debré.
- Technical skills: Flow cytometry and cell sorting, immunological profiling by PCR-Array, BP model of cellular trans-differentiation from blood to skin lesion, murine models of pulmonary inflammation, molecular modelling.
Equipment
- Cell culture labs
- Histopathology and molecular biology equipment
- Autoclave
Patents
- Utilisation des peptides dérivés de l’élastolyse dans la protection et la régénération du parodonte
- Antagonist peptides of the elastin receptor
- Methods and pohamaceuticlas compositions for enhancing NK cell killing activities
- Combinations therapies for the treatment of cancer
Partnerships
Private
Janssen-Cilag (ongoing contract)
Academic
- Reims: Reims university hospital (Departments of dermatology, respiratory diseases, internal medicine and immunology-biology); Jean Godinot Institute; Rare Diseases Reference Center " Malibul, INSERM UMR-S 125
- Paris: INSERM UMR976 Unit, Saint-Louis Hospital; (Dr Bensoussan A) ; Unité UMR_S1016 - UMR8104, ICGM (Pr Batteux F) ; Unité ("IABV") Institut Pasteur (Dr Gougeon ML)
- Lille: INSERM Unit U995 (Pr D. Betbeder, Nanomedicine groupe, Lille International)
- Toulouse : INSERM U1043 (Dr Zazilleau N)
- Europe: Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany
- USA: Division of pulmonary and critical care medicine, St Louis, USA (Pr Richard Pierce)
Specificities
Translational research
Organizational chart